College Football Betting Preview: LSU Vs. Clemson

  • Clemson is favored to beat LSU with -175 odds.
  • There is a 3.5-point spread set for the game.
  • There is a 57.5 point total set between LSU and Clemson.

CLEMSON, S.C. – A top-10 battle of the Death Valley’s is set for Primetime in Week 1 of college football between the #9 LSU Tigers and the #4 Clemson Tigers.

Ahead of kick off, college football prop betting sites have a closely set matchup between the two with just a 3.5-point spread set in favor of Clemson at home here over LSU. There is good reason to believe that Clemson will stay true to their odds to win as well in this one.

#9 LSU Vs. #4 Clemson Odds

  • Moneyline: LSU (+150) vs. Clemson (-175)
  • Spread: Clemson -3.5
  • Total: 57.5

Fade LSU In Non-Conference Season Opener

We’re heavily leaning on Clemson to come out on top in this one on the moneyline. It mainly comes off the fact that LSU has struggled in season openers in recent seasons. They haven’t won a season opener since 2020.

However, since 2021, their season openers have all been nonconference games as well. They lost to UCLA on the road in 2021, Florida State in New Orleans in 2022, FSU again in 2023, and USC in 2024 in Las Vegas.

Getting into the numbers from last season, Clemson finished last season with a +19.3 winning margin when playing at home. As for LSU, they we’re 1-3 against the spread playing on the road and failed to cover the spread on CFB betting sites by a -2.4-point margin.

Since 2023, when Cade Klubnik took over as QB1, they are averaging an 18.3-point winning margin when playing at home.

All time against one another, in four total games, LSU holds the advantage, winning three games to Clemson’s one.

About Samuel Profeta

Sam is a college football enthusiast and who's been on the CollegeFootballProps.com team since 2020. He grew up a Florida State fan and graduated as a Nole in 2019. When he's not chopping it up about the Seminoles CFP snub, he's playing dynasty mode on College Football 25.