- LSU is a 10-point favorite over Clemson in Week 1.
- LSU won 17-10 against Clemson in 2025.
- The game will be Lane Kiffin’s first as the head coach at LSU.
BATON ROUGE, La. – The first College GameDay will take place in Baton Rouge, Louisiana, where LSU is set to take on Clemson in the first game of the home-and-home series. Last year in Clemson, LSU came away with a 17-10 win.
LSU is a sizeable favorite on college football prop betting sites and rightfully so. We’re looking at a 10-point spread in favor of Lane Kiffin’s squad with a 50.5-point over/under.
Clemson Vs. LSU
- Moneyline: Clemson (+300) vs. LSU (-400)
- Spread: LSU -10
- Total: 50.5
$40 Million Pays Off
Look for LSU to hit the ground running here against a weaker-than-normal Clemson squad. LSU’s roster is estimated to be around $40 million, with several notable names committing out of the portal, including 5-Star transfers Sam Leavitt at QB and offensive tackle Jordan Seaton.
Lane Kiffin has done exceptionally well at nearly every program he’s been with and adapted nicely to the transfer portal and NIL era. His roster is made up of 43 total transfers, including 14 4-Stars.
For Clemson, Dabo Swinney is stuck in the past and not willing to adapt to modern-day college football. Clemson is coming off its second-worst season under Dabo Swinney last year with a 7-6 finish both outright and against the spread. They averaged a -3.6-cover margin on the spread as well. Tailing them on South Carolina sportsbooks is one of the riskier bets of the day.
