- Miami is a 16.5-point favorite against Clemson.
- Miami and Clemson are 7-7 against one another.
CLEMSON, S.C. – The #4 Miami Hurricanes are on the road in Week 5 against Clemson. This is the first time the two meet since 2023 and the first time Miami plays in Clemson since 2022.
WEEK 5! 💪
🗓️: October 3rd
🆚: Clemson
📍: Clemson, SC
⏰: 7:30 PM ET
📺: ABC
📻: @1043wqam pic.twitter.com/9k7Vq3ooxi— Miami Hurricanes Football (@CanesFootball) September 29, 2026
Given Miami’s dominance, college football prop betting sites are laying over two touchdowns in favor of the Canes with 16.5 points. Miami comes in undefeated at 4-0, while Clemson is 3-1 and 2-0 in the ACC so far.
Miami Vs. Clemson Betting Lines
- Moneyline: Miami (-900) vs. Clemson (+575)
- Spread: Miami -16.5 (-115)
- Total: 48
Hurricanes Rip Through Clemson
To put into perspective just how much of a decline Clemson has been on this season, this marks the largest underdog spread that Dabo Swinney has ever faced at Clemson, as well as the first time under him that Clemson is a 10+ point underdog at home. Clemson is also 1-4 ATS as a 10+ point underdog in history under Dabo on South Carolina sportsbooks.
This season, Miami is 3-1 against the spread and has been a double-digit favorite in every game. They are covering by +6.5 points on average. Miami is also averaging a +25.5-point winning margin against conference opponents. Clemson is 2-2 ATS with a -4.6 average cover margin.
Miami and Clemson are on opposite ends of the offensive numbers in the ACC. Miami averages 51.8 points on the season and 39 points against ACC opponents. Clemson is down at just 21 points per game, the second lowest in the conference, and 26 points in conference play.
